Articles
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Combinatorial targeting of a chromatin complex comprising Dot1L, menin and the tyrosine kinase BAZ1B reveals new therapeutic vulnerability of endocrine-therapy resistant breast cancerArticleEstrogen receptor alpha (ERα) is a nuclear transcription factor responsible for the regulation of many cell cycle, proliferation, and differentiation genes, especially in breast tissue. Dysregulation of ERα contributes to the formation of breast cancer and is a marker used to determine whether the cancer would be responsive to endocrine therapy. However, many ERα+ breast cancers are unresponsive to endocrine therapy or develop resistance to this treatment strategy. The authors in this paper identify novel combinatorial treatment strategies targeting Dot1L, menin, and BAZ1B.
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ATRX loss in glioma results in dysregulation of cell-cycle phase transition and ATM inhibitor radio-sensitizationArticleATRX is a chromatin remodeler that plays a critical role in transcriptional regulation of cell-cycle control genes. In this study the authors identified Chk1 as a key regulator in the ATRX pathway in glioma. Loss of ATRX is a common occurrence in glioma and increases radiation sensitivity. Upstream inhibitors of Chk1, resulted in increased survival in a mouse brain cancer model and decreased cell proliferation in glioma cell lines.
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Lateral flow assays: The possibilities beyond COVID-19ArticleOriginal Article written and published by News Medical
In this interview, News-Medical talks to Andre Alfaro from nanoComposix (now a Fortis Life Sciences Company) about the possibilities lateral flow assays offer in both the present and potential post-COVID times. -
One Size Fits One - Advancing Infectious Disease Diagnostics With Custom Molecular ReagentsInside Precision MedicineArticleFortis Life Sciences provides customized development and manufacturing of enzymes, reagents, master mixes, and complete test kits for molecular diagnostics and life science applications.
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Age-associated decline of MondoA drives cellular senescence through impaired autophagy and mitochondrial homeostasisArticleA recent study provides mechanistic insights for the involvement of autophagy in cellular senescence. This research shows the transcription factor MondoA controls expression of the autophagy inhibitor Rubicon when senescence is induced.
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