Articles
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Mediobasal hypothalamic FKBP51 acts as a molecular switch linking autophagy to whole-body metabolismArticleFKBP51 expression levels tightly control induction or inhibition of autophagy. In the mediobasal hypothalamus, this regulation of autophagy has a profound impact on obesity.
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Kansl1 haploinsufficiency impairs autophagosome-lysosome fusion and links autophagic dysfunction with Koolen-de Vries syndrome in miceArticleA recent study shows a link between autophagy and a rare genetic disorder, Koolen-de Vries syndrome, caused by loss of KANSL1. An FDA-approved drug, 13-cis retinoic acid, was able to rescue autophagy in the absence of KANSL1.
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USP11 is a potential new therapeutic target to inhibit autophagy in cancerArticleUSP11 promotes autophagy by directly stabilizing Beclin-1. Autophagy is thought to promote tumor progression, and expression of USP11 and Beclin-1 both correlate with poor prognosis in cancer. A recent publication identifies USP11 as a potential therapeutic target to inhibit autophagy in cancer.
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Novel Autophagy Pathway Links CD38 and LRRK2 to TFEB Nuclear TranslocationArticleWhile autophagy is a well-known cellular process used to recycle cytoplasmic contents, the specific pathways and mechanisms of induction are still being elucidated and defined. A recent paper by Neel Nabar and colleagues from the National Institute of Health added new signaling molecules (CD38 and LRRK2) into the autophagy induction pathways.
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Raising the Bar for Biomarkers and Early Diagnostics in Neurodegenerative DiseaseArticleIdentifying novel biomarkers of Parkinson’s disease enables early diagnosis and treatment monitoring.
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